GcMAF, also referred to as DBP-MAF, is really a macrophage activating factor (MAF)
August 31, 2020 Business
Made by enzymatic crystallization of DBP (abbreviation of vitamin D binding protein) in humans; here DBP is really a glycoprotein with about 58,000 The molecular weight of Dalton, owned by the albumin group, is abundantly within the blood, wherein the DBP is with the vitamin D derivative and transported in the blood. The DBP-blood concentration is approximately 300-600 micrograms per milliliter. The sugar side chain is composed of N-acetyl galactosamine, which will be formed by crosslinking of galactose and sialic acid. After immunoactivation, the sugar chain of the GC protein is hydrolyzed by the inducible cell membrane β-galactosidase of B cells to form a macrophage pre-activating factor. The activating factor protein was then hydrolyzed via the cell membrane sialidase (neuraminidase) of activated T cells to the last GcMAF with N-acetaminogalactosamine (GaINAc) as the rest of the residual sugar. This N-acetaminogalactose (GaINAc) is the important thing to the advantages of GcMAF.
The enzyme “Nagalase” (alpha-N-Acetylgalactosaminidase) is really a lysosomal enzyme in the liver that cleaves between GaINAc and the protein’s threonine or serine residues. Bonding. The Nagalase enzyme cleaves the sugar side chain of the Gc protein, thereby losing its precursor activity and not converting to the active GcMAF. Furthermore, Nagalase also inactivates active GcMAF by saccharide cleavage.
Macrophages play a vital role in immune defense and enter the blood with young, immature monocytes from the bone marrow. In the blood, it differentiates into dendritic cells or, after activation, enters the tissue, where it matures into macrophages of resident tissues, and then acts as a Kufu-type stellate cell (liver), glial cells (neural) System), alveolar macrophages (lung), osteoblasts (bone), or Langham’s giant cells (skin).
This GcMAF clearly has great potential for activation of monocytes and macrophages. Even the lowest concentration of antibacterial products that stimulate oxygen free radicals, the “oxidative burst” of monocytes is as much as 50 times. The phagocytic activity and HLA molecular expression increased by a factor of 100, and its antigen presentation can grow exponentially. By this enhanced effect, it’s possible to more effectively combat the pathogens which were previously limited to immunodeficiency. This activates an immune a reaction to an unrecognizable antigen. It can decompose and kill tumor cells which have been immunologically recognized.
The Gcmaf colostrum fermentation must certanly be enriched with vitamin D3. This vitamin D3 is advantageously put into one of many three binding sites of macrophage activating factor (MAF) and the MAF is thus activated.
The fermentation must be enriched with colostrum. The colostrum is employed being an aid in initiating the fermentation. Furthermore, the MAF has three binding sites activated by vitamin D3, colostrum and oleic acid during fermentation.
The fermentation is going to be rich in oleic acid as it is containd in the milk and colostrum. A bonus of the oleic acid is that additionally it may activate MAF by binding to one of many three binding sites of MAF. This is the reason full fat cows milk should continually be used when coming up with gcmaf yogurt.
Important nutrients are offered in a sufficient form for the bacteriological culture in the nutrient medium.
The GcMAF is made by fermentation predicated on a bacterial culture (organism) in that the culture of the bacteria could be obtained. The fermentation is carried out in milk (similar to the preparation of yogurt). The microorganisms useful for fermentation are delivered in powder form. Furthermore, vitamin D3, colostrum and oleic acid are given separately.